I might be one of few Mac users here, but I just switched to using Chome from Safari and Firefox before that. Overall, I'm pretty impressed, though I'm using the latest beta version and there are a few rough edges. It is amazingly quick compared to the other browsers, and I really like the fact that each tab is run in a seperate process. Creating and closing tabs has a very direct and immediate effect on the available system memory, which for someone who is usually pushing the limits of his computer is a very nice thing. The interface is very crisp and minimalistic -- they use tabs ala beta versions of safari 4 where the tabs are part of the title bar of the window which I always liked. Dragging tabs is nice, you can create new windows and they have a slick visual trick of showing a "preview" window as you drag. I slightly prefer the way Safari 4 works though, with its little preview boxes.
From a web development perspective, its just about the same as Safari 4, using the exact same debugging interface. I have noticed a few bugs in it that I didn't see in Safari however. They also haven't fixed the inability to inspect an element inside an iframe.
Overall, its a very fast and stable browser that I'll probably continue to use everyday. Except when I have to test things in IE7. Ugh. :)