I follow byuu and his work on bsnes, and while I don't agree with
everything he says, his ideas on file extensions and particularly the relevance of the headers placed into ROM images make sense to me, since it takes an extra step to add $0200 to locate an address within a ROM.
So I'm considering using a non-headered image to do a refresh of FF6 Improvement, in an attempt to get rid of the patch bloat the last couple of versions have accumulated. But I started thinking about how some of the older fix patches have only one version, and I wanted to check and see if these patches will work with either headered or non-headered versions of a ROM.

Looking back through the board, I see where this came up some time ago, and I see that assassin's patches assume a header is present. Is there any confirmation on the others, like ZED's?